Novel Therapeutic Targeting of CCL3-CCR4 Axis Mediated Apoptotic Intesitnal Injury in Necrotizing Enterocolitis

Novel Therapeutic Targeting of CCL3-CCR4 Axis Mediated Apoptotic Intesitnal Injury in Necrotizing Enterocolitis

BackgroundNecrotizing enterocolitis (NEC) is the leading cause of neonatal gastrointestinal-related death, while the etiology and pathogenesis are poorly understood.MethodsThe levels of CCL3 in intestinal tissue from modeling mice and patients were measured and analyzed. HE staining, TUNEL, Annexin...

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Bibliographic Details
Main Authors: Xi Yuan, Zihan Xiong, Wei Liu, Yue Li, Hongdong Li, Xuemei Zhang, Yibing Yin, Pingyong Xu, Ju Cao, Dapeng Chen, Zhixin Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
NEC
CCL3
CCR4
apoptosis
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.859398/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.859398/full

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