Bioactivity-Guided Synthesis: In Silico and In Vitro Studies of <i>β</i>-Glucosidase Inhibitors to Cope with Hepatic Cytotoxicity

Bioactivity-Guided Synthesis: In Silico and In Vitro Studies of <i>β</i>-Glucosidase Inhibitors to Cope with Hepatic Cytotoxicity

The major cause of hyperglycemia can generally be attributed to β-glucosidase as per its involvement in non-alcoholic fatty liver disease. This clinical condition leads to liver carcinoma (HepG2 cancer). The phthalimides and phthalamic acid classes possess inhibitory potential against glucosidase, f...

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Bibliographic Details
Main Authors: Aneela Khushal, Umar Farooq, Sara Khan, Azhar Rasul, Tanveer A. Wani, Seema Zargar, Sohail Anjum Shahzad, Syed Majid Bukhari, Nazeer Ahmad Khan
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Molecules
Subjects:
β-glucosidase
phthalimide
phthalamic acid
HepG2 cell line
hepatic cytotoxicity
molecular docking
Online Access:https://www.mdpi.com/1420-3049/28/18/6548

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https://www.mdpi.com/1420-3049/28/18/6548

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