Succinate Activates EMT in Intestinal Epithelial Cells through SUCNR1: A Novel Protagonist in Fistula Development

Succinate Activates EMT in Intestinal Epithelial Cells through SUCNR1: A Novel Protagonist in Fistula Development

The pathogenesis of Crohn’s disease-associated fibrostenosis and fistulas imply the epithelial-to-mesenchymal transition (EMT) process. As succinate and its receptor (SUCNR1) are involved in intestinal inflammation and fibrosis, we investigated their relevance in EMT and Crohn’s disease (CD) fistula...

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Bibliographic Details
Main Authors: Dolores Ortiz-Masiá, Laura Gisbert-Ferrándiz, Cristina Bauset, Sandra Coll, Céline Mamie, Michael Scharl, Juan V. Esplugues, Rafael Alós, Francisco Navarro, Jesús Cosín-Roger, María D. Barrachina, Sara Calatayud
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
Crohn’s disease
fistula
succinate
Online Access:https://www.mdpi.com/2073-4409/9/5/1104

Internet

https://www.mdpi.com/2073-4409/9/5/1104

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