The Activation of Mesenchymal Stem Cells by Glioblastoma Microvesicles Alters Their Exosomal Secretion of miR-100-5p, miR-9-5p and let-7d-5p

The Activation of Mesenchymal Stem Cells by Glioblastoma Microvesicles Alters Their Exosomal Secretion of miR-100-5p, miR-9-5p and let-7d-5p

Glioblastoma (GBM) is the most aggressive brain tumor, and despite initial response to chemo- and radio-therapy, the persistence of glioblastoma stem cells (GSCs) unfortunately always results in tumor recurrence. It is now largely admitted that tumor cells recruit normal cells, including mesenchymal...

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Bibliographic Details
Main Authors: Delphine Garnier, Edward Ratcliffe, Joséphine Briand, Pierre-François Cartron, Lisa Oliver, François M. Vallette
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Biomedicines
Subjects:
tumor microenvironment
extracellular vesicles
glioblastoma
MSC activation
exosomal miRNAs
CAFs
Online Access:https://www.mdpi.com/2227-9059/10/1/112

Internet

https://www.mdpi.com/2227-9059/10/1/112

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