GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS

GPX4 deficiency-dependent phospholipid peroxidation drives motor deficits of ALS

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by oxidative stress that triggers motor neurons loss in the brain and spinal cord. However, the mechanisms underlying the exact role of oxidative stress in ALS-associated neural degeneration are not definiti...

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Bibliographic Details
Main Authors: Long-Fang Tu, Tian-Ze Zhang, Yang-Fan Zhou, Qing-Qing Zhou, Hai-Biao Gong, Lei Liang, Lin-Na Hai, Nan-Xin You, Yang Su, Yong-Jun Chen, Xu-Kai Mo, Chang-Zheng Shi, Liang-Ping Luo, Wan-Yang Sun, Wen-Jun Duan, Hiroshi Kurihara, Yi-Fang Li, Rong-Rong He
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Journal of Advanced Research
Subjects:
ALS
Phospholipid peroxidation
GPX4
SOD1G93A transgenic mice
Spinal cord
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123222000601

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http://www.sciencedirect.com/science/article/pii/S2090123222000601

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