Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors

Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors

ABSTRACT The clinical severity and annual occurrence of influenza virus epidemics, combined with the availability of just a single class of antivirals to treat infections, underscores the urgent need to develop new anti-influenza drugs. The endonuclease activity within the viral acidic polymerase (P...

Full description

Bibliographic Details
Main Authors: Jeremy C. Jones, Gyanendra Kumar, Subrata Barman, Isabel Najera, Stephen W. White, Richard J. Webby, Elena A. Govorkova
Format: Article
Language:English
Published: American Society for Microbiology 2018-05-01
Series:mBio
Subjects:
PA polymerase
antiviral
antiviral resistance
endonuclease
influenza virus
Online Access:https://journals.asm.org/doi/10.1128/mBio.00430-18

Internet

https://journals.asm.org/doi/10.1128/mBio.00430-18

Similar Items