To inhibit TrxR1 is to inactivate STAT3–Inhibition of TrxR1 enzymatic function by STAT3 small molecule inhibitors

To inhibit TrxR1 is to inactivate STAT3–Inhibition of TrxR1 enzymatic function by STAT3 small molecule inhibitors

The transcription factor STAT3 plays a key role in cancer and immunity, being widely explored as a potential drug target for the development of novel immunomodulatory or anticancer therapeutics. The mechanisms of small molecule-derived inhibition of STAT3 appear, however, to be more complex than ini...

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Bibliographic Details
Main Authors: Sander Busker, Brent Page, Elias S.J. Arnér
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Redox Biology
Subjects:
Signal transducer and activator of transcription 3
Thioredoxin reductase 1
Small molecule inhibitors
Electrophiles
Selenocysteine
Redox
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172030851X

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http://www.sciencedirect.com/science/article/pii/S221323172030851X

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