2′-O-Methylation of Ribosomal RNA: Towards an Epitranscriptomic Control of Translation?

2′-O-Methylation of Ribosomal RNA: Towards an Epitranscriptomic Control of Translation?

Ribosomal RNA (rRNA) undergoes post-transcriptional modification of over 200 nucleotides, predominantly 2′-O-methylation (2′-O-Me). 2′-O-Methylation protects RNA from hydrolysis and modifies RNA strand flexibility but does not contribute to Watson-Crick base pairing. Th...

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Bibliographic Details
Main Authors: Piero Lo Monaco, Virginie Marcel, Jean-Jacques Diaz, Frédéric Catez
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Biomolecules
Subjects:
2′-O-methylation
ribosomal RNA
fibrillarin
snoRNP
ribosome heterogeneity
mRNA translation
Online Access:http://www.mdpi.com/2218-273X/8/4/106

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