Immune strategies using single-component LipL32 and multi-component recombinant LipL32-41-OmpL1 vaccines against leptospira

Immune strategies using single-component LipL32 and multi-component recombinant LipL32-41-OmpL1 vaccines against leptospira

Genes encoding lipoproteins LipL32, LipL41 and the outer-membrane protein OmpL1 of leptospira were recombined and cloned into a pVAX1 plasmid. BALB/c mice were immunized with LipL32 and recombined LipL32-41-OmpL1 using DNA-DNA, DNA-protein and protein-protein strategies, respectively. Prime immuniza...

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Bibliographic Details
Main Authors: C.Y. Feng, Q.T. Li, X.Y. Zhang, K. Dong, B.Y. Hu, X.K. Guo
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2009-09-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Immune strategy
Recombinant vaccine
Leptospira
Lipoproteins LipL32
LipL41
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000900005

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000900005

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