Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)

Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)

Aggregation of the tau protein into fibrillar cross-β aggregates is a hallmark of Alzheimer’s diseases (AD) and many other neurodegenerative tauopathies. Recently, several core structures of patient-derived tau paired helical filaments (PHFs) have been solved revealing a structural variability that...

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Bibliographic Details
Main Authors: Youssra K. Al-Hilaly, Connor Hurt, Janet E. Rickard, Charles R. Harrington, John M. D. Storey, Claude M. Wischik, Louise C. Serpell, Ansgar B. Siemer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Neuroscience
Subjects:
tau protein
solid-state NMR
amyloid structure
neurodegenerative diseases
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.988074/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2022.988074/full

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