Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)
Aggregation of the tau protein into fibrillar cross-β aggregates is a hallmark of Alzheimer’s diseases (AD) and many other neurodegenerative tauopathies. Recently, several core structures of patient-derived tau paired helical filaments (PHFs) have been solved revealing a structural variability that...
Main Authors: | Youssra K. Al-Hilaly, Connor Hurt, Janet E. Rickard, Charles R. Harrington, John M. D. Storey, Claude M. Wischik, Louise C. Serpell, Ansgar B. Siemer |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-12-01
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Series: | Frontiers in Neuroscience |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.988074/full |
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