Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation

Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation

RAS mutations occur in a broad spectrum of human hematopoietic malignancies. Activating Ras mutations in blood cells leads to hematopoietic malignancies in mice. In murine hematopoietic stem cells (HSCs), mutant N-RasG12D activates Stat5 to dysregulate stem cell function. However, the underlying mec...

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Bibliographic Details
Main Authors: Xi Jin, Victor Ng, Meiling Zhao, Lu Liu, Tomoyasu Higashimoto, Zheng Hong Lee, Jooho Chung, Victor Chen, Gina Ney, Malathi Kandarpa, Moshe Talpaz, Qing Li
Format: Article
Language:English
Published: The Company of Biologists 2022-05-01
Series:Disease Models & Mechanisms
Subjects:
ras signaling
jak/stat signaling
socs proteins
hematopoietic stem cells
leukemia
epigenetic regulation
Online Access:http://dmm.biologists.org/content/15/5/dmm049088

Internet

http://dmm.biologists.org/content/15/5/dmm049088

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