Substantial Effect of Efavirenz Monotherapy on Bilirubin Levels in Healthy Volunteers

Substantial Effect of Efavirenz Monotherapy on Bilirubin Levels in Healthy Volunteers

Background: Efavirenz exhibits multiple interactions with drug-metabolizing enzymes and transporters, and for this reason efavirenz-based HIV therapy is associated with altered pharmacokinetics of coadministered drugs. Probably by the same mechanism, efavirenz-based HIV therapy affects the dispositi...

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Bibliographic Details
Main Authors: Ingrid F. Metzger, PhD, Troy C. Quigg, MD, Noam Epstein, Abdulateef O. Aregbe, MD, Nancy Thong, John T. Callaghan, MD, PhD, David A. Flockhart, MD, PhD, Anne T. Nguyen, Colleen K. Stevens, Samir K. Gupta, Zeruesenay Desta, PhD
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Current Therapeutic Research
Subjects:
anemia
bilirubin disposition
drug interactions
efavirenz
monotherapy
neutropenia
Online Access:http://www.sciencedirect.com/science/article/pii/S0011393X14000095

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http://www.sciencedirect.com/science/article/pii/S0011393X14000095

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