EGCG protects the mouse brain against cerebral ischemia/reperfusion injury by suppressing autophagy via the AKT/AMPK/mTOR phosphorylation pathway

EGCG protects the mouse brain against cerebral ischemia/reperfusion injury by suppressing autophagy via the AKT/AMPK/mTOR phosphorylation pathway

Stroke remains one of the leading reasons of mortality and physical disability worldwide. The treatment of cerebral ischemic stroke faces challenges, partly due to a lack of effective treatments. In this study, we demonstrated that autophagy was stimulated by transient middle cerebral artery occlusi...

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Bibliographic Details
Main Authors: Li Wang, Maosha Dai, Yangyang Ge, Jiayi Chen, Chenchen Wang, Chengye Yao, Yun Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
(−)-epigallocatechin-3-gallate (EGCG)
autophagy
cerebral ischemia/reperfusion injury (CIRI)
middle cerebral artery occlusion/reperfusion (MCAO/R)
oxygen-glucose deprivation/reoxygenation (OGD/R)
HT22 cell
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.921394/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.921394/full

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