The Emergence of Pan-Cancer CIMP and Its Elusive Interpretation

Epigenetic dysregulation is recognized as a hallmark of cancer. In the last 16 years, a CpG island methylator phenotype (CIMP) has been documented in tumors originating from different tissues. However, a looming question in the field is whether or not CIMP is a pan-cancer phenomenon or a tissue-spec...

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Bibliographic Details
Main Authors: Brendan F. Miller, Francisco Sánchez-Vega, Laura Elnitski
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Biomolecules
Subjects:
Online Access:http://www.mdpi.com/2218-273X/6/4/45