Sustained ocular delivery of Dorzolamide-HCl via proniosomal gel formulation: in-vitro characterization, statistical optimization, and in-vivo pharmacodynamic evaluation in rabbits

Sustained ocular delivery of Dorzolamide-HCl via proniosomal gel formulation: in-vitro characterization, statistical optimization, and in-vivo pharmacodynamic evaluation in rabbits

Glaucoma is the second cause of blindness worldwide. Frequent administration of traditional topical dosage forms may lead to patient incompliance and failure of treatment. Our study aims to formulate proniosomal gel formulations that sustain the release of the water-soluble anti-glaucoma drug Dorzol...

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Bibliographic Details
Main Authors: Nagwa Hussein Fouda, Randa Tag Abdelrehim, Doaa Abdelmagid Hegazy, Basant Ahmed Habib
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Drug Delivery
Subjects:
full factorial design
prediction interval
interaction plot
intraocular pressure
bioavailability
Online Access:http://dx.doi.org/10.1080/10717544.2018.1477861

Internet

http://dx.doi.org/10.1080/10717544.2018.1477861

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