Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice
There are currently no effective therapies available for acute kidney injury (AKI). Here the authors generate molybdenum-based polyoxometalate nanoclusters and show that these have preferential renal uptake and can ameliorate AKI pathology in mice by scavenging reactive oxygen species.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07890-8 |
| _version_ | 1831827661664550912 |
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| author | Dalong Ni Dawei Jiang Christopher J. Kutyreff Jianhao Lai Yongjun Yan Todd E. Barnhart Bo Yu Hyung-Jun Im Lei Kang Steve Y. Cho Zhaofei Liu Peng Huang Jonathan W. Engle Weibo Cai |
| author_facet | Dalong Ni Dawei Jiang Christopher J. Kutyreff Jianhao Lai Yongjun Yan Todd E. Barnhart Bo Yu Hyung-Jun Im Lei Kang Steve Y. Cho Zhaofei Liu Peng Huang Jonathan W. Engle Weibo Cai |
| author_sort | Dalong Ni |
| collection | DOAJ |
| description | There are currently no effective therapies available for acute kidney injury (AKI). Here the authors generate molybdenum-based polyoxometalate nanoclusters and show that these have preferential renal uptake and can ameliorate AKI pathology in mice by scavenging reactive oxygen species. |
| first_indexed | 2024-12-23T02:04:57Z |
| format | Article |
| id | doaj.art-5959a910616a4c1bb0a94672ebd75639 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:04:57Z |
| publishDate | 2018-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5959a910616a4c1bb0a94672ebd756392022-12-21T18:03:54ZengNature PortfolioNature Communications2041-17232018-12-019111110.1038/s41467-018-07890-8Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in miceDalong Ni0Dawei Jiang1Christopher J. Kutyreff2Jianhao Lai3Yongjun Yan4Todd E. Barnhart5Bo Yu6Hyung-Jun Im7Lei Kang8Steve Y. Cho9Zhaofei Liu10Peng Huang11Jonathan W. Engle12Weibo Cai13Departments of Radiology and Medical Physics, University of WisconsinDepartments of Radiology and Medical Physics, University of WisconsinDepartments of Radiology and Medical Physics, University of WisconsinDepartments of Radiology and Medical Physics, University of WisconsinDepartments of Radiology and Medical Physics, University of WisconsinDepartments of Radiology and Medical Physics, University of WisconsinDepartments of Radiology and Medical Physics, University of WisconsinDepartments of Radiology and Medical Physics, University of WisconsinDepartments of Radiology and Medical Physics, University of WisconsinDepartments of Radiology and Medical Physics, University of WisconsinMedical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science CenterGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen UniversityDepartments of Radiology and Medical Physics, University of WisconsinDepartments of Radiology and Medical Physics, University of WisconsinThere are currently no effective therapies available for acute kidney injury (AKI). Here the authors generate molybdenum-based polyoxometalate nanoclusters and show that these have preferential renal uptake and can ameliorate AKI pathology in mice by scavenging reactive oxygen species.https://doi.org/10.1038/s41467-018-07890-8 |
| spellingShingle | Dalong Ni Dawei Jiang Christopher J. Kutyreff Jianhao Lai Yongjun Yan Todd E. Barnhart Bo Yu Hyung-Jun Im Lei Kang Steve Y. Cho Zhaofei Liu Peng Huang Jonathan W. Engle Weibo Cai Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice Nature Communications |
| title | Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice |
| title_full | Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice |
| title_fullStr | Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice |
| title_full_unstemmed | Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice |
| title_short | Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice |
| title_sort | molybdenum based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice |
| url | https://doi.org/10.1038/s41467-018-07890-8 |
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