The Relationship Between Population Attributable Fraction and Heritability in Genetic Studies

Population attributable fraction (PAF) has been widely used to quantify the proportion of disease risk in a population that can be attributed to risk factors in epidemiological studies. However, the use of PAF has been limited in assessing the contribution of genetic variants. Most notably, the PAF...

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Bibliographic Details
Main Authors: Tao Wang, H. Dean Hosgood, Qing Lan, Xiaonan Xue
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00352/full