Untangling Macropore Formation and Current Facilitation in P2X7
Macropore formation and current facilitation are intriguing phenomena associated with ATP-gated P2X7 receptors (P2X7). Macropores are large pores formed in the cell membrane that allow the passage of large molecules. The precise mechanisms underlying macropore formation remain poorly understood, but...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/13/10896 |
| _version_ | 1797591549856448512 |
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| author | Federico Cevoli Benoit Arnould Francisco Andrés Peralta Thomas Grutter |
| author_facet | Federico Cevoli Benoit Arnould Francisco Andrés Peralta Thomas Grutter |
| author_sort | Federico Cevoli |
| collection | DOAJ |
| description | Macropore formation and current facilitation are intriguing phenomena associated with ATP-gated P2X7 receptors (P2X7). Macropores are large pores formed in the cell membrane that allow the passage of large molecules. The precise mechanisms underlying macropore formation remain poorly understood, but recent evidence suggests two alternative pathways: a direct entry through the P2X7 pore itself, and an indirect pathway triggered by P2X7 activation involving additional proteins, such as TMEM16F channel/scramblase. On the other hand, current facilitation refers to the progressive increase in current amplitude and activation kinetics observed with prolonged or repetitive exposure to ATP. Various mechanisms, including the activation of chloride channels and intrinsic properties of P2X7, have been proposed to explain this phenomenon. In this comprehensive review, we present an in-depth overview of P2X7 current facilitation and macropore formation, highlighting new findings and proposing mechanistic models that may offer fresh insights into these untangled processes. |
| first_indexed | 2024-03-11T01:39:02Z |
| format | Article |
| id | doaj.art-595d1290953c438d935e4a4116b16b75 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T01:39:02Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-595d1290953c438d935e4a4116b16b752023-11-18T16:45:09ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-06-0124131089610.3390/ijms241310896Untangling Macropore Formation and Current Facilitation in P2X7Federico Cevoli0Benoit Arnould1Francisco Andrés Peralta2Thomas Grutter3Équipe de Chimie et Neurobiologie Moléculaire, Laboratoire de Conception et Application de Molécules Bioactives (CAMB) UMR 7199, Centre National de la Recherche Scientifique, Faculté de Pharmacie, Université de Strasbourg, 67401 Illkirch, FranceÉquipe de Chimie et Neurobiologie Moléculaire, Laboratoire de Conception et Application de Molécules Bioactives (CAMB) UMR 7199, Centre National de la Recherche Scientifique, Faculté de Pharmacie, Université de Strasbourg, 67401 Illkirch, FranceÉquipe de Chimie et Neurobiologie Moléculaire, Laboratoire de Conception et Application de Molécules Bioactives (CAMB) UMR 7199, Centre National de la Recherche Scientifique, Faculté de Pharmacie, Université de Strasbourg, 67401 Illkirch, FranceÉquipe de Chimie et Neurobiologie Moléculaire, Laboratoire de Conception et Application de Molécules Bioactives (CAMB) UMR 7199, Centre National de la Recherche Scientifique, Faculté de Pharmacie, Université de Strasbourg, 67401 Illkirch, FranceMacropore formation and current facilitation are intriguing phenomena associated with ATP-gated P2X7 receptors (P2X7). Macropores are large pores formed in the cell membrane that allow the passage of large molecules. The precise mechanisms underlying macropore formation remain poorly understood, but recent evidence suggests two alternative pathways: a direct entry through the P2X7 pore itself, and an indirect pathway triggered by P2X7 activation involving additional proteins, such as TMEM16F channel/scramblase. On the other hand, current facilitation refers to the progressive increase in current amplitude and activation kinetics observed with prolonged or repetitive exposure to ATP. Various mechanisms, including the activation of chloride channels and intrinsic properties of P2X7, have been proposed to explain this phenomenon. In this comprehensive review, we present an in-depth overview of P2X7 current facilitation and macropore formation, highlighting new findings and proposing mechanistic models that may offer fresh insights into these untangled processes.https://www.mdpi.com/1422-0067/24/13/10896P2X7current facilitationATP sensitizationmacropore formation |
| spellingShingle | Federico Cevoli Benoit Arnould Francisco Andrés Peralta Thomas Grutter Untangling Macropore Formation and Current Facilitation in P2X7 International Journal of Molecular Sciences P2X7 current facilitation ATP sensitization macropore formation |
| title | Untangling Macropore Formation and Current Facilitation in P2X7 |
| title_full | Untangling Macropore Formation and Current Facilitation in P2X7 |
| title_fullStr | Untangling Macropore Formation and Current Facilitation in P2X7 |
| title_full_unstemmed | Untangling Macropore Formation and Current Facilitation in P2X7 |
| title_short | Untangling Macropore Formation and Current Facilitation in P2X7 |
| title_sort | untangling macropore formation and current facilitation in p2x7 |
| topic | P2X7 current facilitation ATP sensitization macropore formation |
| url | https://www.mdpi.com/1422-0067/24/13/10896 |
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