RNA Binding Motif Protein RBM45 Regulates Expression of the 11-Kilodalton Protein of Parvovirus B19 through Binding to Novel Intron Splicing Enhancers

RNA Binding Motif Protein RBM45 Regulates Expression of the 11-Kilodalton Protein of Parvovirus B19 through Binding to Novel Intron Splicing Enhancers

ABSTRACT During infection of human parvovirus B19 (B19V), one viral precursor mRNA (pre-mRNA) is transcribed by a single promoter and is alternatively spliced and alternatively polyadenylated. Here, we identified a novel cis-acting sequence (5′-GUA AAG CUA CGG GAC GGU-3′), intronic splicing enhancer...

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Bibliographic Details
Main Authors: Jianke Wang, Safder S. Ganaie, Fang Cheng, Peng Xu, Kang Ning, Xiaomei Wang, Steve Kleiboeker, Shipeng Cheng, Jianming Qiu
Format: Article
Language:English
Published: American Society for Microbiology 2020-04-01
Series:mBio
Subjects:
RBM45
mRNA splicing
intron splicing enhancer
parvovirus B19
11-kDa protein
RNA binding proteins
Online Access:https://journals.asm.org/doi/10.1128/mBio.00192-20

Internet

https://journals.asm.org/doi/10.1128/mBio.00192-20

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