Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema

Abstract Senescence, a hallmark of aging, is a factor in age-related diseases (ARDs). Therefore, targeting senescence is widely regarded as a practicable method for modulating the effects of aging and ARDs. Here, we report the identification of regorafenib, an inhibitor of multiple receptor tyrosine...

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Bibliographic Details
Main Authors: Jung-Jin Park, Kwangseok Oh, Gun-Wu Lee, Geul Bang, Jin-Hee Park, Han-Byeol Kim, Jin Young Kim, Eun-Young Shin, Eung-Gook Kim
Format: Article
Language:English
Published: Nature Publishing Group 2023-04-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-023-00966-6