Hepatic nuclear factor 4 alpha promotes the ferroptosis of lung adenocarcinoma via transcriptional activation of cytochrome P450 oxidoreductase

Background Lung adenocarcinoma is one of the most prevalent cancers while ferroptosis is crucial for cancer therapies. This study aims to investigate the function and mechanism of hepatic nuclear factor 4 alpha (HNF4A) in lung adenocarcinomas’ ferroptosis. Materials and Methods HNF4A expression in f...

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Bibliographic Details
Main Authors: Valeria Besskaya, Huan Zhang, Yunyi Bian, Jiaqi Liang, Guoshu Bi, Guangyao Shan, Cheng Zhan, Zongwu Lin
Format: Article
Language:English
Published: PeerJ Inc. 2023-05-01
Series:PeerJ
Subjects:
Online Access:https://peerj.com/articles/15377.pdf