Dual anti-inflammatory activities of COX-2/5-LOX driven by kratom alkaloid extracts in lipopolysaccharide-induced RAW 264.7 cells

Dual anti-inflammatory activities of COX-2/5-LOX driven by kratom alkaloid extracts in lipopolysaccharide-induced RAW 264.7 cells

Abstract Cyclooxygenase (COX) and lipoxygenase (LOX) enzymes play a pivotal role in producing pro-inflammatory eicosanoids, including prostaglandins (PGs) and leukotrienes (LTs), in the inflammation process. Mitragynine is a primary alkaloid contained in the kratom’s leaves and has been reported to...

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Bibliographic Details
Main Authors: Siti Irma Rahmawati, Dwi Wahyu Indriani, Febby Nurdiya Ningsih, Mutia Hardhiyuna, Firdayani Firdayani, Peni Ahmadi, A’liyatur Rosyidah, Eris Septiana, Ni Luh Putu Indi Dharmayanti, Asep Bayu, Masteria Yunovilsa Putra
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Mitragyna speciosa
Cellular oxidative stress
Dual inhibition COX-2/5-LOX
Anti-inflammatory
Online Access:https://doi.org/10.1038/s41598-024-79229-x

Internet

https://doi.org/10.1038/s41598-024-79229-x

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