Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer

Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer

<i>Trillium tschonoskii</i> Maxim (TTM), a traditional Chinese medicine, has been demonstrated to have a potent anti-tumor effect. Recently, polyphyllin VI (PPVI), a main saponin isolated from TTM, was reported by us to significantly suppress the proliferation of non-small cell lung canc...

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Bibliographic Details
Main Authors: Jin-Feng Teng, Qi-Bing Mei, Xiao-Gang Zhou, Yong Tang, Rui Xiong, Wen-Qiao Qiu, Rong Pan, Betty Yuen-Kwan Law, Vincent Kam-Wai Wong, Chong-Lin Yu, Han-An Long, Xiu-Li Xiao, Feng Zhang, Jian-Ming Wu, Da-Lian Qin, An-Guo Wu
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Cancers
Subjects:
nsclc
polyphyllin vi
pyroptosis
ros/nf-κb/nlrp3/gsdmd
Online Access:https://www.mdpi.com/2072-6694/12/1/193

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https://www.mdpi.com/2072-6694/12/1/193

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