Production and characterization of a chimeric antigen, based on nucleocapsid of SARS-CoV-2 fused to the extracellular domain of human CD154 in HEK-293 cells as a vaccine candidate against COVID-19.

Production and characterization of a chimeric antigen, based on nucleocapsid of SARS-CoV-2 fused to the extracellular domain of human CD154 in HEK-293 cells as a vaccine candidate against COVID-19.

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Despite that more than one hundred vaccines against SARS-CoV-2 have been developed and that some of them were evaluated in clinical trials, the latest results revealed that these vaccines still face great challenges. Among the components of the virus, the N-protein constitutes an attractive target f...

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Bibliographic Details
Main Authors: Thailin Lao, Ileanet Avalos, Elsa María Rodríguez, Yasser Zamora, Alianet Rodriguez, Ailyn Ramón, Yanitza Alvarez, Ania Cabrales, Ivan Andújar, Luis Javier González, Pedro Puente, Cristina García, Leonardo Gómez, Rodolfo Valdés, Mario Pablo Estrada, Yamila Carpio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0288006&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0288006&type=printable

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