Inhibitory Fc-Gamma IIb Receptor Signaling Induced by Multivalent IgG-Fc Is Dependent on Sialylation

Inhibitory Fc-Gamma IIb Receptor Signaling Induced by Multivalent IgG-Fc Is Dependent on Sialylation

Immunoglobulin (IgG) Fc glycosylation has been shown to be important for the biological activity of antibodies. Fc sialylation is important for the anti-inflammatory activity of IgGs. However, evaluating the structure–activity relationship (SAR) of antibody Fc glycosylation has been hindered using s...

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Bibliographic Details
Main Authors: Christopher Beneduce, Stephanie Nguyen, Nathaniel Washburn, John Schaeck, Robin Meccariello, Kimberly Holte, Daniel Ortiz, Anthony M. Manning, Carlos J. Bosques, Elma Kurtagic
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
immunoglobulin Fc
sialylation
therapeutics
FcγRIIb
Online Access:https://www.mdpi.com/2073-4409/12/17/2130

Internet

https://www.mdpi.com/2073-4409/12/17/2130

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