The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes.

The Guinea Pig as a Model for Sporadic Alzheimer's Disease (AD): The Impact of Cholesterol Intake on Expression of AD-Related Genes.

We investigated the guinea pig, Cavia porcellus, as a model for Alzheimer's disease (AD), both in terms of the conservation of genes involved in AD and the regulatory responses of these to a known AD risk factor - high cholesterol intake. Unlike rats and mice, guinea pigs possess an Aβ peptide...

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Bibliographic Details
Main Authors: Mathew J Sharman, Seyyed H Moussavi Nik, Mengqi M Chen, Daniel Ong, Linda Wijaya, Simon M Laws, Kevin Taddei, Morgan Newman, Michael Lardelli, Ralph N Martins, Giuseppe Verdile
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3689723?pdf=render

Internet

http://europepmc.org/articles/PMC3689723?pdf=render

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