Involvement of striatal motoric subregions in familial frontotemporal dementia with parkinsonism harboring the C9orf72 repeat expansions

Abstract The chromosome 9 open reading frame 72 (C9ORF72) has been proposed as the causative gene of frontotemporal dementia with parkinsonism (FTDP), but its pathophysiological mechanism of parkinsonism is poorly understood. To explore the roles of striatal motor subdivisions in the pathogenesis of...

Full description

Bibliographic Details
Main Authors: Li Liu, Shuying Liu, Min Chu, Jingjuan Wang, Kexin Xie, Yue Cui, Jinghong Ma, Haitian Nan, Chunlei Cui, Hongwen Qiao, Pedro Rosa-Neto, Piu Chan, Liyong Wu
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-022-00398-5