‘Social’ versus ‘asocial’ cells—dynamic competition flux balance analysis

Abstract In multicellular organisms cells compete for resources or growth factors. If any one cell type wins, the co-existence of diverse cell types disappears. Existing dynamic Flux Balance Analysis (dFBA) does not accommodate changes in cell density caused by competition. Therefore we here develop...

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Bibliographic Details
Main Authors: Yanhua Liu, Hans V. Westerhoff
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-023-00313-5