Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis

Inhibitors of recombinant protein-tyrosine phosphatase 1B (PTP1B) from Khaya senegalensis: Towards a strategic target for therapeutic intervention in trypanosomiasis

Background: Tyrosine dephosphorylation, catalyzed by protein-tyrosine phosphatase (PTP), prevents trypanosome differentiation to a procyclic form that lacks diverse mechanisms for survival within the mammalian host's bloodstream. Thus, differentiation to a procyclic form in the mammalian host&#...

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Bibliographic Details
Main Authors: Fatima Amin Adamude, Ikenna Nnamdi Ezeaku, Abraham Ehinomhen Ubhenin, Ifeanyi Peter Onyeka, Ahmad Adamu Ambi, Ikechukwu Robert Uroko, Emeka John Dingwoke
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Phytomedicine Plus
Subjects:
Human African Trypanosomiasis
Cell signaling
Trypanosome differentiation
Procyclic trypanosome
Protein-tyrosine phosphatase
Inhibition, myristic acid analog
Online Access:http://www.sciencedirect.com/science/article/pii/S2667031322001063

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http://www.sciencedirect.com/science/article/pii/S2667031322001063

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