ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems

ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems

Abstract Background Many favorable traits of crops and livestock and human genetic diseases arise from multiple single nucleotide polymorphisms or multiple point mutations with heterogeneous base substitutions at the same locus. Current cytosine or adenine base editors can only accomplish C-to-T (G-...

Full description

Bibliographic Details
Main Authors: Jingke Xie, Xingyun Huang, Xia Wang, Shixue Gou, Yanhui Liang, Fangbing Chen, Nan Li, Zhen Ouyang, Quanjun Zhang, Weikai Ge, Qin Jin, Hui Shi, Zhenpeng Zhuang, Xiaozhu Zhao, Meng Lian, Jiaowei Wang, Yinghua Ye, Longquan Quan, Han Wu, Kepin Wang, Liangxue Lai
Format: Article
Language:English
Published: BMC 2020-09-01
Series:BMC Biology
Subjects:
Adenine and cytosine base editor (ACBE)
Simultaneous C-to-T and A-to-G conversions
Mammalian systems
Online Access:http://link.springer.com/article/10.1186/s12915-020-00866-5

Internet

http://link.springer.com/article/10.1186/s12915-020-00866-5

Similar Items