A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP

A Silent Operon of Photorhabdus luminescens Encodes a Prodrug Mimic of GTP

ABSTRACT With the overmining of actinomycetes for compounds acting against Gram-negative pathogens, recent efforts to discover novel antibiotics have been focused on other groups of bacteria. Teixobactin, the first antibiotic without detectable resistance that binds lipid II, comes from an unculture...

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Bibliographic Details
Main Authors: Negar Shahsavari, Boyuan Wang, Yu Imai, Miho Mori, Sangkeun Son, Libang Liang, Nils Böhringer, Sylvie Manuse, Michael F. Gates, Madeleine Morrissette, Rachel Corsetti, Josh L. Espinoza, Chris L. Dupont, Michael T. Laub, Kim Lewis
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mBio
Subjects:
antibiotic resistance
natural product
nucleoside analog
Online Access:https://journals.asm.org/doi/10.1128/mbio.00700-22

Internet

https://journals.asm.org/doi/10.1128/mbio.00700-22

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