Decitabine priming increases anti–PD-1 antitumor efficacy by promoting CD8+ progenitor exhausted T cell expansion in tumor models

Decitabine priming increases anti–PD-1 antitumor efficacy by promoting CD8+ progenitor exhausted T cell expansion in tumor models

CD8+ exhausted T cells (Tex) are heterogeneous. PD-1 inhibitors reinvigorate progenitor Tex, which subsequently differentiate into irresponsive terminal Tex. The ability to maintain a capacity for durable proliferation of progenitor Tex is important, but the mechanism remains unclear. Here, we showe...

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Podrobná bibliografie
Hlavní autoři: Xiang Li, Yaru Li, Liang Dong, Yixin Chang, Xingying Zhang, Chunmeng Wang, Meixia Chen, Xiaochen Bo, Hebing Chen, Weidong Han, Jing Nie
Médium: Článek
Jazyk:English
Vydáno: American Society for Clinical Investigation 2023-04-01
Edice:The Journal of Clinical Investigation
Témata:
Immunology
Oncology
On-line přístup:https://doi.org/10.1172/JCI165673

Internet

https://doi.org/10.1172/JCI165673

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