Impaired oxygen extraction and adaptation of intracellular energy metabolism in cerebral small vessel disease

Impaired oxygen extraction and adaptation of intracellular energy metabolism in cerebral small vessel disease

Background: We aimed to investigate whether combined phosphorous (31P) magnetic resonance spectroscopic imaging (MRSI) and quantitative T2′ mapping are able to detect alterations of the cerebral oxygen extraction fraction (OEF) and intracellular pH (pHi) as markers the of cellular energy metabolism...

Full description

Bibliographic Details
Main Authors: Annemarie Reiländer, Ulrich Pilatus, Jan-Rüdiger Schüre, Manoj Shrestha, Ralf Deichmann, Ulrike Nöth, Elke Hattingen, René-Maxime Gracien, Marlies Wagner, Alexander Seiler
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cerebral Circulation - Cognition and Behavior
Subjects:
Small vessel disease
Oxygen extraction fraction
Cellular energy metabolism
MR spectroscopy
quantitative MRI
Microstructural impairment
Online Access:http://www.sciencedirect.com/science/article/pii/S2666245023000065

Internet

http://www.sciencedirect.com/science/article/pii/S2666245023000065

Similar Items