Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model

Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based LRP2 knockout human kidney cell model

Abstract Background Megalin (LRP2 receptor) mediates the endocytosis of radiolabeled peptides into proximal tubular kidney cells, which may cause nephrotoxicity due to the accumulation of a radioactive tracer. The study aimed to develop a cellular model of human kidney HK2 cells with LRP2 knockout (...

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Bibliographic Details
Main Authors: Anna Durinova, Lucie Smutna, Pavel Barta, Rajamanikkam Kamaraj, Tomas Smutny, Bernhard Schmierer, Petr Pavek, Frantisek Trejtnar
Format: Article
Language:English
Published: SpringerOpen 2024-04-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Radiolabeled peptide
LRP2
Megalin
CRISPR/Cas9
Radionephrotoxicity
Online Access:https://doi.org/10.1186/s41181-024-00262-2

Internet

https://doi.org/10.1186/s41181-024-00262-2

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