Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential

Mitochondrial dysfunction in Parkinson’s disease – a key disease hallmark with therapeutic potential

Abstract Mitochondrial dysfunction is strongly implicated in the etiology of idiopathic and genetic Parkinson’s disease (PD). However, strategies aimed at ameliorating mitochondrial dysfunction, including antioxidants, antidiabetic drugs, and iron chelators, have failed in disease-modification clini...

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Bibliographic Details
Main Authors: Martin T. Henrich, Wolfgang H. Oertel, D. James Surmeier, Fanni F. Geibl
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Molecular Neurodegeneration
Subjects:
Parkinson’s disease
Synuclein
Mitochondria
Mitochondrial dysfunction
MPTP
Electron transport chain
Online Access:https://doi.org/10.1186/s13024-023-00676-7

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