Bmp7 maintains undifferentiated kidney progenitor population and determines nephron numbers at birth.

Bmp7 maintains undifferentiated kidney progenitor population and determines nephron numbers at birth.

The number of nephrons, the functional units of the kidney, varies among individuals. A low nephron number at birth is associated with a risk of hypertension and the progression of renal insufficiency. The molecular mechanisms determining nephron number during embryogenesis have not yet been clarifi...

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Bibliographic Details
Main Authors: Mayumi Tomita, Misako Asada, Nariaki Asada, Jin Nakamura, Akiko Oguchi, Atsuko Y Higashi, Shuichiro Endo, Elizabeth Robertson, Takeshi Kimura, Toru Kita, Aris N Economides, Jordan Kreidberg, Motoko Yanagita
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3753328?pdf=render

Internet

http://europepmc.org/articles/PMC3753328?pdf=render

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