P300/CBP-Associated Factor Activates Cardiac Fibroblasts by SMAD2 Acetylation

P300/CBP-Associated Factor Activates Cardiac Fibroblasts by SMAD2 Acetylation

Various heart diseases cause cardiac remodeling, which in turn leads to ineffective contraction. Although it is an adaptive response to injury, cardiac fibrosis contributes to this remodeling, for which the reactivation of quiescent myofibroblasts is a key feature. In the present study, we investiga...

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Bibliographic Details
Main Authors: Yongwoon Lim, Anna Jeong, Duk-Hwa Kwon, Yeong-Un Lee, Young-Kook Kim, Youngkeun Ahn, Taewon Kook, Woo-Jin Park, Hyun Kook
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
cardiac fibrosis
cardiac fibroblasts
P300/CBP-associated factor
transforming growth factor-β1, acetylation
posttranslational modification
Online Access:https://www.mdpi.com/1422-0067/22/18/9944

Internet

https://www.mdpi.com/1422-0067/22/18/9944

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