Single-nucleus transcriptomics of IDH1- and TP53-mutant glioma stem cells displays diversified commitment on invasive cancer progenitors

Single-nucleus transcriptomics of IDH1- and TP53-mutant glioma stem cells displays diversified commitment on invasive cancer progenitors

Abstract Glioma is a devastating brain tumor with a high mortality rate attributed to the glioma stem cells (GSCs) possessing high plasticity. Marker mutations in isocitrate dehydrogenase type 1 (IDH1) and tumor protein 53 (TP53) are frequent in gliomas and impact the cell fate decisions. Understand...

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Bibliographic Details
Main Authors: Valeriia Gulaia, Mikhail Shmelev, Aleksander Romanishin, Nikita Shved, Vladislav Farniev, Nikolay Goncharov, Arthur Biktimirov, Irene Lisa Vargas, Konstantin Khodosevich, Alexander Kagansky, Vadim Kumeiko
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-23646-3

Internet

https://doi.org/10.1038/s41598-022-23646-3

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