Structural activity of synthesized pyrimidine-thiophene and pyrimidine-thiadiazole conjugates as anticancer agents

Structural activity of synthesized pyrimidine-thiophene and pyrimidine-thiadiazole conjugates as anticancer agents

New pyrimidine linked thiophene conjugates 5a-d and thiadiazole conjugates 7a-d through a carboxamide bridge were synthesized and characterized by the spectral data (IR, NMR and mass). Exploration of the isolated conjugates’ characteristics using DFT methodology revealed that they had angular config...

Full description

Bibliographic Details
Main Authors: Abeer Mogadem, Abrar Bayazeed, Abdulmajeed F. Alrefaei, Sara A. Alqarni, Jihan Qurban, Majid A. Bamaga, E.F.M. El-Zaidia, Nashwa M. El-Metwaly
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Results in Chemistry
Subjects:
Pyrimidine-thiophene
Pyrimidine-thiadiazole
Modelling
Carbonic anhydrases
SwissADME
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715624005095

Internet

http://www.sciencedirect.com/science/article/pii/S2211715624005095

Similar Items