NTRK1 knockdown induces mouse cognitive impairment and hippocampal neuronal damage through mitophagy suppression via inactivating the AMPK/ULK1/FUNDC1 pathway

NTRK1 knockdown induces mouse cognitive impairment and hippocampal neuronal damage through mitophagy suppression via inactivating the AMPK/ULK1/FUNDC1 pathway

Abstract Hippocampal neuronal damage may induce cognitive impairment. Neurotrophic tyrosine kinase receptor 1 (NTRK1) reportedly regulates neuronal damage, although the underlying mechanism remains unclear. The present study aimed to investigate the role of NTRK1 in mouse hippocampal neuronal damage...

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Bibliographic Details
Main Authors: Kai Yang, Jue Wu, Shang Li, Shan Wang, Jing Zhang, Yi-peng Wang, You-sheng Yan, Hua-ying Hu, Ming-fang Xiong, Chao-bo Bai, Yong-qing Sun, Wen-qi Chen, Yang Zeng, Jun-liang Yuan, Cheng-hong Yin
Format: Article
Language:English
Published: Nature Publishing Group 2023-10-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01685-7

Internet

https://doi.org/10.1038/s41420-023-01685-7

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