Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis.

Probing the antigenicity of hepatitis C virus envelope glycoprotein complex by high-throughput mutagenesis.

The hepatitis C virus (HCV) envelope glycoproteins E1 and E2 form a non-covalently linked heterodimer on the viral surface that mediates viral entry. E1, E2 and the heterodimer complex E1E2 are candidate vaccine antigens, but are technically challenging to study because of difficulties in producing...

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Bibliographic Details
Main Authors: Radhika Gopal, Kelli Jackson, Netanel Tzarum, Leopold Kong, Andrew Ettenger, Johnathan Guest, Jennifer M Pfaff, Trevor Barnes, Andrew Honda, Erick Giang, Edgar Davidson, Ian A Wilson, Benjamin J Doranz, Mansun Law
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-12-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5749897?pdf=render

Internet

http://europepmc.org/articles/PMC5749897?pdf=render

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