Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction

Complement induces podocyte pyroptosis in membranous nephropathy by mediating mitochondrial dysfunction

Abstract Podocyte damage mediated by in situ complement activation in the glomeruli is a key factor in the pathogenesis of membranous nephropathy (MN), but the molecular mechanism has not been fully elucidated. Pyroptosis is a special type of programmed cell death, mediate inflammatory response and...

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Bibliographic Details
Main Authors: Hui Wang, Daoyuan Lv, Song Jiang, Qing Hou, Lei Zhang, Shen Li, Xiaodong Zhu, Xiaodong Xu, Jianqiang Wen, Caihong Zeng, Mingchao Zhang, Fan Yang, Zhaohong Chen, Chunxia Zheng, Jing Li, Ke Zen, Zhihong Liu, Limin Li
Format: Article
Language:English
Published: Nature Publishing Group 2022-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04737-5

Internet

https://doi.org/10.1038/s41419-022-04737-5

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