Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis

Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis

Objective: Uncoupling protein 1 (UCP1) catalyses mitochondrial proton leak in brown adipose tissue to facilitate nutrient oxidation for heat production, and may combat metabolic disease if activated in humans. During the adrenergic stimulation of brown adipocytes, free fatty acids generated from lip...

Full description

Bibliographic Details
Main Authors: Riccardo Cavalieri, Marlou Klein Hazebroek, Camila A. Cotrim, Yang Lee, Edmund R.S. Kunji, Martin Jastroch, Susanne Keipert, Paul G. Crichton
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Molecular Metabolism
Subjects:
Ligand binding
Thermal stability assay
Differential scanning fluorimetry
Brown adipose tissue
Proton transport
Energy expenditure
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877822000953

Internet

http://www.sciencedirect.com/science/article/pii/S2212877822000953

Similar Items