Integrative Analysis of Proteomics and DNA Methylation in Orbital Fibroblasts From Graves’ Ophthalmopathy

Integrative Analysis of Proteomics and DNA Methylation in Orbital Fibroblasts From Graves’ Ophthalmopathy

BackgroundGraves’ ophthalmopathy (GO) is a frequent extrathyroidal complication of Graves’ hyperthyroidism. Orbital fibroblasts contribute to both orbital tissue inflammation and remodeling in GO, and as such are crucial cellular elements in active GO and inactive GO. However, so far it is largely u...

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Bibliographic Details
Main Authors: Sita Virakul, Poorichaya Somparn, Trairak Pisitkun, Peter J. van der Spek, Virgil A. S. H. Dalm, Dion Paridaens, P. Martin van Hagen, Nattiya Hirankarn, Tanapat Palaga, Willem A. Dik
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Endocrinology
Subjects:
graves’ ophthalmopathy
orbital fibroblast
proteomics
DNA methylation
epigenetics
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2020.619989/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2020.619989/full

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