A Novel 5-Chloro-<i>N</i>-phenyl-1<i>H</i>-indole-2-carboxamide Derivative as Brain-Type Glycogen Phosphorylase Inhibitor: Potential Therapeutic Effect on Cerebral Ischemia

A Novel 5-Chloro-<i>N</i>-phenyl-1<i>H</i>-indole-2-carboxamide Derivative as Brain-Type Glycogen Phosphorylase Inhibitor: Potential Therapeutic Effect on Cerebral Ischemia

Brain-type glycogen phosphorylase inhibitors are potential new drugs for treating ischemic brain injury. In our previous study, we reported compound <b>1</b> as a novel brain-type glycogen phosphorylase inhibitor with cardioprotective properties. We also found that compound <b>1<...

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Bibliographic Details
Main Authors: Yatao Huang, Shuai Li, Youde Wang, Zhiwei Yan, Yachun Guo, Liying Zhang
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
brain-type glycogen phosphorylase inhibitor
mouse astrocytes
glycolysis
apoptosis
oxidative phosphorylation
Online Access:https://www.mdpi.com/1420-3049/27/19/6333

Internet

https://www.mdpi.com/1420-3049/27/19/6333

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