Bacteria‐Elicited Specific Thrombosis Utilizing Acid‐Induced Cytolysin A Expression to Enable Potent Tumor Therapy

Bacteria‐Elicited Specific Thrombosis Utilizing Acid‐Induced Cytolysin A Expression to Enable Potent Tumor Therapy

Abstract Given the special microenvironment of solid tumors, live microorganisms have emerged as drug delivery vehicles and therapeutic agents. Here, an acid‐induced therapeutic platform is constructed using attenuated Escherichia coli to express the cytolysin A protein. The bacteria can target and...

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Bibliographic Details
Main Authors: Wenjun Qin, Wenxuan Xu, Longyu Wang, Debao Ren, Yibin Cheng, Wen Song, Tao Jiang, Lixin Ma, Cheng Zhang
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:Advanced Science
Subjects:
acid‐induced
bacteria
nutrient interruption
thrombosis
tumor therapy
Online Access:https://doi.org/10.1002/advs.202105086

Internet

https://doi.org/10.1002/advs.202105086

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