Folate affects neural tube development through KDM6A
Objective To investigate the effects of lysine-specific demethylase 6A (KDM6A) on neural tube defects (NTDs) in low folate environment. Methods Mouse embryonic stem cells (SV129), NTD mouse models and NTD human specimens were used. SV129 cells were incubated with 0.02 μmol/L methotrexate (MTX) for 2...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2020-02-01
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| Series: | Jichu yixue yu linchuang |
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| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/a190168.pdf |