Metformin Attenuates Cardiac Hypertrophy Via the HIF-1α/PPAR-γ Signaling Pathway in High-Fat Diet Rats

Metformin Attenuates Cardiac Hypertrophy Via the HIF-1α/PPAR-γ Signaling Pathway in High-Fat Diet Rats

Coronary artery disease (CAD) and cardiac hypertrophy (CH) are two main causes of ischemic heart disease. Acute CAD may lead to left ventricular hypertrophy (LVH). Long-term and sustained CH is harmful and can gradually develop into cardiac insufficiency and heart failure. It is known that metformin...

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Bibliographic Details
Main Authors: Yuansheng Liu, Qian Zhang, Lei Yang, Wencong Tian, Yinan Yang, Yuhang Xie, Jing Li, Liang Yang, Yang Gao, Yang Xu, Jie Liu, Yachen Wang, Jie Yan, Guoxun Li, Yanna Shen, Zhi Qi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
coronary artery disease
cardiac hypertrophy
high-fat diet
metformin
HIF-1α
PPAR-γ
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.919202/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.919202/full

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