Control of Listeria monocytogenes infection requires classical IL-6 signaling in myeloid cells.

Control of Listeria monocytogenes infection requires classical IL-6 signaling in myeloid cells.

IL-6 is required for the response of mice against Listeria monocytogenes. Control of infection depends on classical IL-6 signaling via membrane IL-6Rα, but IL-6 target cells and protective mechanisms remain unclear. We used mice with IL-6Rα-deficiency in T cells (Il6rafl/fl×CD4cre) or myeloid cells...

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Bibliographic Details
Main Authors: Karsten Lücke, Isabell Yan, Sonja Krohn, Annika Volmari, Stefanie Klinge, Joanna Schmid, Valéa Schumacher, Oliver M Steinmetz, Stefan Rose-John, Hans-Willi Mittrücker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6118394?pdf=render

Internet

http://europepmc.org/articles/PMC6118394?pdf=render

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